Advancements in Gastroretentive Floating Drug Delivery Systems: A Comprehensive Review on Famotidine-Based Formulations

Abstract

GRFDDS have been of great interest because they can enhance the bioavailability and therapeutic efficacy of drugs absorbed in the stomach and upper gastrointestinal (GI) tract. One of the common antagonists of the H2-receptor is famotidine, which has shown to be effective in the treatment of the gastrointestinal disorders associated with acid. But it has low bioavailability due to its low retention time in the stomach. GRFDDS is designed to address this drawback and achieve a controlled and sustained release of drug, thus improving the effect of the therapeutic action of famotidine. This review will give a detailed discussion of the different categories of gastroretentive floating system namely famotidine in an effervescent, non-effervescent and other novel methods of delivering famotidine. The review continues to discuss the formulation strategies, major determiners of floating behavior, and benefits and challenges of such systems. Moreover, it emphasizes recent advances and future outlooks of the design and optimization of floating drug delivery systems, particularly famotidine. These systems can provide an excellent solution to the clinical efficacy of famotidine to improve patient compliance and disease control by increasing the gastric retention time.