A Review: Anti-Alzheimer Potential of Rungia pectinata

Abstract

This review summarizes modern studies on the phytochemical profile, pharmacological actions, and mechanisms underlying the neuroprotective effects of the plant. The most important bioactivities identified are antioxidant, anti-inflammatory, and acetylcholinesterase inhibitory activities, which are crucial in countering the pathological mechanisms of Alzheimer’s disease progression. Neuroinflammation and oxidative stress damage neurons in Alzheimer’s disease, and the anti-oxidant and anti-inflammatory compounds in Rungia pectinata  have the potential to reduce these effects. In addition, blocking acetylcholinesterase, an enzyme that breaks down acetylcholine, can augment cholinergic neurotransmission, which is usually damaged in patients with Alzheimer’s disease. The pharmacological research is an experimental support of these activities with a promise of the plant as a source of neuroprotective agents. Although these results are encouraging, there are still concerns regarding standardization of extracts, understanding of specific molecular targets, and clinical trials to prove efficacy. The direction of future research is that pharmacodynamic and toxicological analyses require thorough evaluation to enable the application of Rungia pectinata  to the neurodegenerative conditions. Therefore, this review is a starting point for investigating the therapeutic value of Rungia pectinata  in the management of Alzheimer’s disease.