Formulation and Evaluation of Cefadroxil-Hyaluronic Acid Micro Emulgel: A Dual-Action Approach for Acne Treatment and Enhanced Skin Hydration

Abstract

A large percentage of people, especially teenagers and young adults, suffer from acne, a prevalent dermatological ailment. The purpose of this study was to create and assess a novel micro emulgel formulation that combined the powerful moisturizing ingredient hyaluronic acid with the second-generation cephalosporin antibiotic cefadroxil. The objective was to develop a dual-action topical medication that improves skin moisture while simultaneously targeting the bacteria that causes acne. Using different doses of the active components, three distinct formulations (F1, F2, and F3) were created, and their drug content, viscosity, particle size, zeta potential, pH, and in vitro drug release were all assessed. F1 had the best physicochemical characteristics and release profile of all the formulations.

The formulations' promise as a therapeutic option was supported by stability studies, which verified their effectiveness under a range of storage circumstances. By addressing both the microbiological and hydrating components of acne therapy, this research offers insights into the creation of an efficient dual-action micro emulgel that could greatly enhance patient outcomes and satisfaction.