Synthesis and Biological Evaluation of 1,4-Dihydropyridine Derivatives as Anti-inflammatory Agents

Abstract

The new 1,4-dihydropyridine drug series emerged from Swiss Target Prediction's design process. Testing showed these compounds had peak binding ability with COX-II receptor. The research team created six top-performing 1,4-Dihydropyridine variations through ethyl acetoacetate and aromatic benzaldehyde replacements. Our team used UV and IR instruments to study the basic structure of each compound. All tested compounds underwent paw edema testing using rats to measure their biological effects. New compounds showed the highest anti-inflammatory performance first (3d) followed by 3b, 3e and 3c. These effects placed better than 3a and 3f. The substance 3d displayed superior anti-inflammatory results because its extra strength comes from both the methoxy electron withdrawing site and the chlorine electron donating group found in 1,4 dihydropyridines. Each of these groups works to make rats less inflamed.