Recent updates on the synthesis and clinical evaluation of Styryl Benzene Imidazole used in Pharmaceutical Preparations

Abstract

Styryl benzene imidazole is synthesized directly in a single reaction step by condensation of cinnamaldehyde with o-phenylenediamine using a catalyst such as boric acid in the water solvent, that successfully forming a molecule of "styryl-benzimidazole" in which the styryl group is directly attached to the benzimidazole ring. The molecule of "styryl benzene imidazole" consists of a benzene ring directly connected to an imidazole ring (forming a benzimidazole unit), with a styryl group (a vinyl group with a phenyl ring attached) extending from one of the carbon atoms of the imidazole ring. The drug treats conditions such as hyperplasia of smooth muscle cells, which are generally caused by revascularization surgery and organ transplantation. Styryl benzimidazole can reversibly change color upon exposure to light due to isomerization between the cis and trans forms.