Synthesis and Biological Evaluation of 1,4-Dihydropyridine Derivatives as Anti-inflammatory Agents

Abstract

1,4-dihydropyridine nucleus has been used as an anti-inflammatory. Derivatives designed by using Swiss Target Prediction. This study revealed maximum COX-II receptor binding activity. The six most promising derivatives of 1,4-Dihydropyridine were synthesized by the substitution of aromatic benzaldehyde with ethyl acetoacetate. Subsequently, spectral analyses were conducted utilizing UV and IR spectrophotometry. The In-Vivo assessments (biological evaluations) of all synthesized compounds were executed employing the paw edema model in rats. The anti-inflammatory efficacy of the synthetic compounds is in the following order: 3d>3b>3e>3c>3a>3f. Due to the presence of the electron-donating chlorine group and the electron-withdrawing methoxy group in the 1,4-dihydropyridine derivatives, compound 3d demonstrated superior activity relative to the other compounds. These two functional groups enhance the anti-inflammatory activity observed in the rat model.